Enantioselective Extraction of Ofloxacin Enantiomers Using Ester Alcohol L-Tartarate as Chiral Selector

نویسندگان

  • Xinyu Jiang School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, CHINA
چکیده مقاله:

The distribution behavior of ofloxacin enantiomers was examined in the aqueous and organic solvent of a two-phase system containing chiral selector L-tartarate. The effect of extraction equilibrium time, buffer pH, organic solvents and length of alkyl chain of L-tartarate on the partition coefficients and enantioselectivity of racemic ofloxacin were investigated, respectively. The L-tartarate formed more stable complexes with R-ofloxacin than that with S-ofloxacin. The partition coefficients and enantioselectivity of racemic ofloxacin increased with increasing length of alkyl chain of L-tartarate. Solvents showed a large influence on enantioselectivity and partition coefficients. Optimum buffer pH was about 7 for separation of racemic ofloxacin by extraction.  

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enantioselective extraction of ofloxacin enantiomers using ester alcohol l-tartarate as chiral selector

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عنوان ژورنال

دوره 28  شماره 1

صفحات  7- 11

تاریخ انتشار 2009-03-01

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